Sam Kean · 400 pages
Rating: (7.2K votes)
“In these days before antiseptics, doctors themselves also suffered high mortality rates. Florence Nightingale, a nurse during the Crimean War (1853-1856), watched one particularly inept surgeon cut both himself and, somehow, a bystander while blundering about during an amputation. Both men contracted an infection and died, as did the patient. Nightingale commented that it was the only surgery she'd ever seen with 300 percent mortality.”
“Biologists summarize these hypothalamic duties as the "four F's" of animal behavior—feeding, fleeing, fighting, and, well, sexual congress.”
“In this thinking, the mind’s conscious, decision-making “will” is actually a by-product of whatever the unconscious brain has already decided to do. Free will is a retrospective illusion, however convincing, and we feel “urges” to do only what we’re going to do anyway. Pride alone makes us insist otherwise.”
“Above all, we know that there’s a physical basis for every psychological attribute we have: if just the right spot gets damaged, we can lose just about anything in our mental repertoire, no matter how sacred.”
“different sets of facial muscles—and therefore produce different-looking smiles. This divergence explains the difference between genuine smiles and fakey, say-cheese smiles in photographs. People have trouble faking other genuine expressions, too, like fear, surprise, or an interest in someone’s pet stories. To overcome this limitation actors either drill with a mirror and practice conjuring up facial expressions à la Laurence Olivier, or, à la Constantin Stanislavsky, they inhabit the role and replicate the character’s internal feelings so closely that the right expressions emerge naturally.) The limbic system, and the temporal lobes generally, are also closely tied up with sex. Scientists discovered this connection in a roundabout way. In the mid-1930s a rogue biologist named Heinrich Klüver started some”
“Confederate surgeons usually performed “circular” amputations. They made a 360-degree cut through the skin, then scrunched it up like a shirt cuff. After sawing through the muscle and bone, they inched the skin back down to wrap the stump. This method led to less scarring and infection. Union surgeons preferred “flap” amputations: doctors left two flaps of flesh hanging beside the wound to fold over after they’d sawed through. This method was quicker and provided a more comfortable stump for prosthetics. Altogether, surgeons lopped off 60,000 fingers, toes, hands, feet, and limbs during the war.”
“You can think about this decoupling as the converse of neurons that fire together wire together. Here, neurons out of sync fail to link.”
“It was the bad luck of eating patient zero.”
“Other people found Capgras syndrome erotic. One Frenchwoman in the 1930s had complained for years about her awkward lover; luckily, his double proved a stud. Male victims liked that their wives’ bodies seemed electrifyingly new every few weeks. (One cheeky doctor has even declared the syndrome the secret to connubial bliss, since each sexual encounter feels fresh.)”
“The twentieth century’s first major discovery about vision came about, once again, because of war. Russia had long coveted a warm-water port on the Pacific Ocean, so in 1904 the czar sent hundreds of thousands of troops to Manchuria and Korea to bully one away from the Japanese. These soldiers were armed with high-speed rifles whose tiny, quarter-inch bullets rocketed from the muzzle at fourteen hundred miles per hour. Fast enough to penetrate the skull but small enough to avoid messy shattering, these bullets made clean, precise wounds like worm tracks through an apple. Japanese soldiers who were shot through the back of the brain—through the vision centers, in the occipital lobe—often woke up to find themselves with tiny blind spots, as if they were wearing glasses spattered with black paint. Tatsuji Inouye, a Japanese ophthalmologist, had the uncomfortable job of calculating how much of a pension these speckled-blind soldiers should receive, based on the percentage of vision lost. Inouye could have gotten away”
“We crowned ourselves Homo sapiens, the wise ape, but Homo limbus might have been more apt.”
“B1 to harvest energy from glucose, the end result of digesting carbohydrates. Brain cells especially rely on glucose for energy, since other sugars cannot cross the blood-brain barrier. The brain also needs thiamine to make myelin sheaths and to build certain neurotransmitters.”
“Noyes’s sex-crazed utopian cult in Oneida, New York.”
“People fluent in two languages can lose either one after trauma, since first and second languages* draw on distinct neural circuits. Language deficits can even interfere with math. We seem to have a natural “number circuit” in the parietal lobe that handles comparisons and magnitudes—the basis of most arithmetic. But we learn some things (like the times tables) linguistically, by rote memorization. So if language goes kaput, so too will those linguistically based skills. More strikingly, some people who struggle to string even three words together can sing just fine.”
“Rope-a-dope boxers and quarterbacks and hockey enforcers continue to shake off concussions on the theory of no blood, no harm. But each concussion effectively softens up the brain and ups the chances of more concussions. After multiple blows, neurons start to die and spongy holes open up; people’s personalities then disintegrate, leaving them depressed, diminished, suicidal. Four centuries have passed, but macho modern athletes* might as well trade pads for armor and go joust with”
“During dreams, the pons also dispatches a message to the spinal cord beneath it, which produces chemicals to make your muscles flaccid. This temporary paralysis prevents you from acting out nightmares by fleeing the bedroom or taking swings at werewolves. While”
“Negative experiences can wire neurons together, too.”
“frontal lobes includes suppressing impulses from the parietal lobes, which are curious and capricious and, as the lobes most intimately involved with touch, want to explore everything tactilely. So when certain parts of the frontal lobe go kaput, the brain can no longer tamp down these parietal impulses, and the hand begins to flail and grab. (Neurologically, this flaring up of suppressed impulses resembles the “release” of the snout reflex in kuru victims.) And because the grasping impulse springs from the subconscious, the conscious brain can’t always interrupt it and break the hand’s grip. Hand-to-hand combat—with”
“a fully plastic brain “learns everything and remembers nothing.”
“Yet he could somehow still feel that missing four-fifths of himself—still feel pain in his invisible fingers, still feel his invisible toes twitching. “Often at night I would try with one lost hand to grope for the other,” he recalled, but the ghosts always eluded him.”
“These axons can shuttle information around so quickly because they’re fatter than normal axons, and because they’re sheathed in a fatty substance called myelin. Myelin acts like rubber insulation on wires and prevents the signal from petering out: in whales, giraffes, and other stretched creatures, a sheathed neuron can send a signal multiple yards with little loss of fidelity. (In contrast, diseases that fray myelin, like multiple sclerosis, destroy communication between different nodes in the brain.) In sum, you can think about the gray matter as a patchwork of chips that analyze different types of information, and about the white matter as cables that transmit information between those chips. (And before we go further, I should point out that “gray” and “white” are misnomers. Gray matter looks pinkish-tan inside a living skull, while white matter, which makes up the bulk of the brain, looks pale pink. The white and gray colors appear only after you soak the brain in preservatives. Preservatives also harden the brain, which is normally tapioca-soft. This explains why the brain you might have dissected in biology class way back when didn’t disintegrate between your fingers.)”
“Ale jest też inny prawdopodobny powód odmowy trepanacji królewskiej głowy - ryzyko powikłań po takim zabiegu było wysokie, a winnym z pewnością byłby przeprowadzający go lekarz'.”
“Whenever we read about people's lives, fictional or non-, we have to put ourselves into the minds of the characters. And honestly, my mind has never had to stretch so far, never had to work so hard, as it did to inhabit the minds of people with brain damage. They're recognizably human in so many ways, and yet still somehow off: Hamlet seems transparent next to H.M. But that's the power of stories, to reach across that divide.”
“Niestety, choć to okrutne, silny cios w głowę może zaburzyć zdroworozsądkowy osąd, gdy potrzeba go najbardziej (...)”
“This hinted at something that no one had ever suspected -- that the brain tracks moving things more easily that still things. We have a built-in bias toward detecting action. Why? Because it's probably more critical for animals to spot moving things (predators, prey, falling trees) than static things, which can wait. In fact, our vision is so biased toward movement that we don't technically see stationary objects at all. To see something stationary, our brains have to scribble our eyes subtly over its surface. Experiments have even proven that if you artificially stabilize an image on the retina with a combination of special contact lenses and microelectronics, the image will vanish.”
“In fact, his travelogues spend amazingly little time discussing his blindness. Only one passage stands out for its frank discussion of his handicap and how it changed his worldview. In it, Holman was reminiscing about a few rendezvous from his past. Disarmingly, he admitted that he had no idea what his paramours looked like, or even whether they were homely. Moreover, he didn't care: by abandoning the standards of the sighted world, he argues, he could tap into a more divine and more authentic beauty. Hearing a woman's voice and feeling her caresses -- and then filling in what was missing with his own fancy -- gave him more pleasure than the mere sight of a women ever had, he said, a pleasure beyond reality. "Are there any who imagine," Holman asked, "that my loss of eyesight must necessarily deny me the enjoyment of such contemplation? How much more do I pity the mental darkness which could give rise to such an error.”
“Bez układu limbicznego powtarzanie tych samych błędów w ogóle nie było denerwujące. Właściwie małpy przestały wykazywać jakiekolwiek emocje. Nic już ich nie gniewało, nie cieszyło, nie smuciło'.”
“Niemożność dostrzeżenia szerszego kontekstu to zwykły skutek uszkodzenia okolic kory przedczołowej, a dotknięci tą przypadłością pacjenci często nie mogą posunąć się dalej niż jeden czy dwa kroki na drodze do realizacji jakiegokolwiek zadania'.”
“Temporal lobe lesions can flip people’s sexual orientations from gay to straight (or vice versa), or redirect their sexual appetites toward inappropriate things: common side effects of Klüver-Bucy include zoophilia, coprophilia, pedophilia, and -philias so idiosyncratic they don’t have names.”
“He didn't just kiss, he claimed ownership. Took her mouth with urgency, as if his life depended on his kissing her.”
“The impression of strength came from an extraordinary vitality that seemed to pulse in the very air around him”
“He sighed. "You want to live in your church, going about your life as if you're like everyone else."
"So?"
"You aren't. And because of that, someday you're probably going to find yourself in a position where your choices will have an impact far beyond what you see right now. And when that happens, I want you to remember what it's like to ride through the woods on horseback under a night sky with no moon and nothing stronger than you are. I want you to know so you will fight for it. So that my children will know of it. You have to keep the demons where they are, Rachel. No one else can do it. You won't fight for us unless you know. Let me show you what you're fighting for.”
“What’s a pandemonium?” whispered one of the men in the rear.
“It’s like a calliope,” answered a companion. “I heard one played at the Harmony Fair last summer, when I went there to see my sister’s boy play his organ.”
“His what?”
“His organ.”
“Lord. People pay money to see things like that?”
“He had relieved whores beyond counting of frocks, stays, chemises, garters, and stockings. He had never before in his life unbuttoned a gently bred maiden's glove. He'd committed salacious acts beyond number. He'd never before felt so depraved as he did now, as the last pearl came free and he drew the soft kid down, baring her wrist, and his dark fingers grazed the delicate skin he'd exposed.”
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