The Poisoner's Handbook: Murder and the Birth of Forensic Medicine in Jazz Age New York

In a best-selling book, 100,000,000 Guinea Pigs (reprinted nine times by 1935), a pair of consumer-advocate authors complained that American citizens had become test animals for chemical industries that were indifferent to their customers' well-being. The government, they added bitterly, was complicit.

There was the Bennett Cocktail (gin, lime juice, bitters), the Bee’s Knees (gin, honey, lemon juice), the Gin Fizz (gin, lemon juice, sugar, seltzer water), and the Southside (lemon juice, sugar syrup, mint leaves, gin, seltzer water).

In his examination of the young dial painters, he’d discovered a fact that was impossible to dismiss. The women were exhaling radon gas.

I see poisoners—so calculating, so cold-blooded—as most like the villains of our horror stories. They’re closer to that lurking monster in the closet than some drug-impaired crazy with a gun. I don’t mean to dismiss the latter—both can achieve the same awful results. But the scarier killer is the one who thoughtfully plans his murder ahead, tricks a friend, wife, lover into swallowing something that will dissolve tissue, blister skin, twist the muscles with convulsions, knows all that will happen and does it anyway.

Standard Oil issued a cool response: “These men probably went insane because they worked too hard,” according to the building manager. And those who didn’t survive had merely worked themselves to death. Other than that, the company didn’t see a problem.

From almost every standpoint ethyl alcohol must be regarded as the most important poison with which medical men and jurists have to deal,” Gettler wrote in a paper, listing a seemingly endless record of fatalities. “No other poison causes so many deaths or leads to or intensifies so many diseases, both physical and mental, as does [this] alcohol in the many forms in which it is taken.

Nicotine had been isolated and synthesized in the nineteenth century. In pure form, it took an ounce at most to kill the average adult.

a cloudy cocktail called Smoke, made by mixing water and fuel alcohol. Smoke joints were tucked into the back of paint stores, drugstores, and markets, among the dry goods and the stacked cans.

Although traditional weapons killed far more people in the Great War, poison gas gave a new nightmare edge to the fighting.

That same January the city government had released a report declaring that thanks to ill-informed, corrupt, and occasionally drunken coroners, murderers in New York were escaping justice in record numbers.

The name explains the structure: carbon, hydrogen, and oxygen bond into a ring-shaped structure called a cresol (also found in creosote), and phosphorus hangs on to the ring like an exhausted swimmer gripping a life preserver.

SCIENTISTS HAD KNOWN since the late nineteenth century that tobacco smoke contains carbon monoxide. Victorian scientists had even been able to calculate the amount of gas in the smoke: up to 4 percent in cigarette smoke, and in Gettler’s own choice of tobacco, the cigar, between 6 and 8 percent. Gettler’s latest work theorized that chain smokers might suffer from low-level carbon monoxide poisoning. He speculated in a 1933 report that “headaches experienced by heavy smokers are due in part to the inhalation of carbon monoxide.” But his real interest lay less in their symptoms than in how much of the poison had accumulated in their blood, and how that might affect his calculations on cause of death. He approached that problem in his usual, single-minded way. To get a better sense of carbon monoxide contamination from smoking tobacco, Gettler selected three groups of people to compare: persons confined to a state institution in the relatively clean air of the country; street cleaners who worked in a daily, dusty cloud of car exhaust; and heavy smokers. As expected, carboxyhemoglobin blood levels for country dwellers averaged less than 1 percent saturation. The levels for Manhattan street cleaners were triple that amount, a solid 3 percent. But smokers came in the highest, higher than he’d expected, well above the nineteenth-century calculations. Americans were inhaling a lot more tobacco smoke than they had once done, and their saturation levels ranged from 8 to 19 percent. (The latter was from a Bronx cab driver who admitted to smoking six cigarettes on his way to Gettler’s laboratory, lighting one with the stub of another as he went.) It was safe to assume, Gettler wrote with his usual careful precision, that “tobacco smoking appreciably increases the carbon monoxide in the blood and cannot be ignored in the interpretation of laboratory results.” THE OTHER NOTABLE poison in tobacco smoke was nicotine.